|
KMID : 0385019960120010123
|
|
Korean Journal of Laboratory Animal Science
1996 Volume.12 No. 1 p.123 ~ p.130
|
|
|
Peri-and Post-natal Studies for Ginkgo biloba Extract in Rats
|
|
이영순/Lee, Yong Soon
남정석/제정환/이석만/양재만/강병철/이학모/Nam, Jeong Seok/Che, Jeong Hwan/Lee, Suk Man/Yang, Jae Man/Kang, Byeong Cheol/Lee, Hak Mo
|
|
|
Abstract
|
|
|
Reproductive toxicity in peri- and post-natal periods for Ginkgo biloba, a herb medicine extracted from leaves of ginkgo tree.
The Sprague-Dawley rats were used and maximum tolerant dosage (30㎎/㎏) of clinical dose. was considered high dosage and with constant ratio(×1/2) 3 experimental groups including high dose (30㎎/㎏) , medium dose (15㎎/㎏), low dose (7.5㎎/㎏) and medium control group were established. Each group was consist of 20 pregnant rats, from pregnancy 16 days to 21 days after delivery Ginkgo biloba extract was injected throgh tail vein of mother(F0) a tune a day, observing whether it raised reproductive toxicity in mother and the fetus.
In F0 no abnormality in general symptom, body weight, food consumption, pregnancy period, delivery- and lactation was observed thought to be caused by this material, although there are a few items having statistical significance in the effect on next generation (F1) after delivery, autopsy findings of F0 and reproductive ability test, but the appearance was independent an dosage and the trend through whole experimental period was not consistent, so, we could conclude there was no differences thought to be related to the material.
Therefore, Ginkgo biloba extract being injected with dosage lower than 30㎎/㎏/day was concluded to have no effect in peri- and post-natal periods.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|